The weekend is a time of transition between Friday night and Monday morning. Everyone in the world of T.O.E, almost without exception, blacks out at 12 a.m. Friday night and wakes up sometime on Monday, exactly where they were on Friday. It is exceedingly rare to see anyone awake on the weekend, though some beings are capable of maintaining consciousness on Saturday and Sunday.
The weekend appears to have a strong connection to codespace, and those creatures that traverse codespace can also avoid the effects of the weekend. The full extent of this connection is unknown.